How is this even possible? Unbelievable change!

You guys aren't going to believe this! I can't believe it myself, it's so far fetched. I started taking Entresto last Friday morning, my doctor prescribed the lowest dose and said to cut it in half so I could be very slowly acclimated. Well... I braced myself for the side effects and was fully prepared to "take on" this newest challenge. I decided to stay with my Mom in town in case there were complications from it and even bought my usual 'gentle foods' for the weekend. 

Friday went well, there were no new symptoms to add to my menagerie of side effects already plaguing me. I thought to myself... buckle up baby, this is going to be a rough one. I waited... but I had decided to be positive and keep my mind occupied with relaxing, fun things. Mom and I were pleasantly surprised when the entire day went by and besides about an hour of low blood pressure and my usual lethargic feeling, I was tolerating the Entresto well. I felt hopeful and went to bed. 

Here's where it gets interesting... So the next morning I awoke just before 5am to a sensation I hadn't felt in a LONG time. I felt energetic! I wanted to DO something! I looked around my room at Mom's (which is my home away from home) and decided it needed an overhaul. Long story short, I got up and was measuring and figuring, and planning... all while feeling so perky I didn't know WHAT to do with the energy. I thought it was a fluke because sometimes I get like that for a couple of hours and it just drops back to my usual lethargy. But... it didn't. Saturday I was still full of energy, but afraid to do too much. My mood had shifted from helpless to hopeful in a matter of 24 hours. I told Mom my plans to overhaul my room so it could have more space, but also added that I would get my daughter to help me the following day so I wouldn't over do. In the mean time, I was giddy with anticipation.

Sunday... I woke up feeling the same! I couldn't wait to tackle my room and began sorting and cleaning and getting the space ready for change. It was exhilarating!!! My daughter came over and helped move the heavy things and I was able to do the rest. Both Mom and my daugher Alicia were in awe watching me and worried I was doing too much, but it was so much fun, they just let me at it. 

Monday... I again woke up earlier than usual, even though I thought I would be tired from not getting 10 hours of sleep the last three nights, more like 7-8. But I felt GREAT! After leaving Mom's to come home, I had such a sense of accomplishment. My hubby and I are getting new furnature soon and when I got home, I noticed the big old chair from our living room was gone, he donated it to the neighbor. Anyway, I immediately felt like tidying the house! I couldn't stop. All the months and years of not being able to do much of anything... that was the driving force. Before I knew it, I had finished all the little things that had been driving me nuts. All the while my hubby was looking on in amazement! He kept voicing concern that I might be over doing it, but I just couldn't stop. I rested between tasks, and was careful.

So... this morning I woke up before 6am and was so inspired, I tackled my closet!!! It had gotten quite unloved as of late and I felt like fixing it, so I did, before breakfast, before my tea, and whipped it into shape. 

It's more than just energy, I'm perky, and I feel like this emotional burden has lifted. WHAT is in THIS STUFF??? LOL! Could I have FINALLY found what my body needs to get better??? It sure seems that way. At any rate, I've had the best 4 days and hope it continues. I am just baffled at how it could work so quickly and so WELL. I'm a completely different person. 

Thanks for sharing my journey, I appreciate all of you. 


5 Comments

You are right: I don't believe this . . .

by Gemita - 2024-04-09 12:24:27

Now Janene, can we really get excited?  Are we going to beat this and have we found those magic missing ingredients?

I see Entresto contains two active ingredients sacubitril (a neprilysin inhibitor), and valsartan (an angiotensin receptor blocker). Entresto works by blocking the changes caused by the enzyme neprilysin, and angiotensin-II.  As a result, blood vessels relax and less water is kept by the body which is useful to treat heart failure.  Now were you missing those two vital ingredients in your body? 

Whatever you are taking now, don’t change anything or increase anything while you are doing so well.  It will be a combination of meds, of different treatments that might just make a difference.

This really doesn’t seem possible but well done for bravely starting Entresto.  Do you feel your sleep is improved with Entresto?

I attach a link on Entresto.  The two active substances in Entresto, sacubitril and valsartan, work in different ways. Sacubitril blocks the breakdown of natriuretic peptides produced in the body. Natriuretic peptides cause sodium and water to pass into the urine thereby reducing the strain on the heart. They also reduce blood pressure and protect the heart from developing fibrosis (scar tissue) that occurs in heart failure.

Valsartan is an ‘angiotensin-II-receptor antagonist’, which means that it blocks the action of a hormone called angiotensin II. The effects of angiotensin II can be harmful in patients with heart failure. By blocking the receptors (targets) to which angiotensin II normally attaches, valsartan stops the hormone’s harmful effects on the heart and also reduces blood pressure by allowing blood vessels to widen.  

Don't stop what you are currently doing Janene, but please don't overdo it.

https://www.ema.europa.eu/en/medicines/human/EPAR/entresto

Congrats!

by Buzbuz9 - 2024-04-09 12:26:06

That is awesome! I am glad you got to find meds that work for you after so long. I am hoping you have many more energetic days to come :)

Congrats..

by USMC-Pacer - 2024-04-09 16:52:37

I'm not sure of a timeline, but if Entresto is limiting, or even stopping your PVCs and allowing your CRT to do it's thing at a high %, I would think that would give you a boost! Glad you're feeling better :)

Fantastic News

by SeenBetterDays - 2024-04-10 07:07:11

Hi R2D2,

It sounds like this new medication has been transformational and I am so pleased that this has happened for you.  You have been through a lot and have eloquently expressed how difficult it has been having such restrictions and limitations prior to this point.  It's just so lovely to hear your positive progress and that you now feel able to do so many of the things you enjoy. Long may it continue!

Rebecca x

Seen better days... thank you!

by R2D2 - 2024-04-10 11:58:02

I hope so too! Aside from some pretty low blood pressure (86/58 this morning) that lasts an hour or so, I'm still doing really well compared to before Entresto. At this point, any improvement is greatly welcomed. 

You know you're wired when...

You run like the bionic man.

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