Colchicine and statin

Newbie here - thank you all for this club and forum.

I had a PM implanted 2 months ago. Been having several issues which are another topic. One is suspected inflammation. The doctor just prescribed colchicine, a double dose (.6mg x 2/day). The pharmacist said there is increased risk of muscle breakdown and other serious side effects when taken with statins.  I am already on 15mg of Atorvastatin. I don't want to trade one set of problems for another. Anyone have experience with the combination of these 2 drugs?

Thnx,

4 Comments

Drug interactions

by Julros - 2023-11-23 01:49:05

Did your pharmacist advise you to contact your prescriber? From what I can find online, yes, there is the potential for side effects and I hope someone advised you what to report. Your dose of atorvastatin is relatively low, and if you do not have pre-existing kidney disease, then your risk is lower. 

I have no personal experience with colchicine, but I've administered it and seems to be effective, if you can tolerate the side effects. Most anti-inflammatories have side effects, so your provider has to weigh benefits versus negatives. 

I hope you get relief soon from your inflammation. 

Colchicine and Statins

by Gemita - 2023-11-23 03:49:00

Solomon, I agree with Julros, that you should go back to your doctor for further guidance and reassurance of possible interactions with Statins.  Colchicine is an extremely effective, powerful anti inflammatory.  It is usually prescribed for short periods whenever possible. 

A family member has gout and has taken Colchicine while on a Statin (Rosuvastatin) but for short periods only (a few days).  Colchicine has been extremely “effective” in treating his acute gout flare ups, but it can be hard on the stomach.  He is now taking regular doses of Allopurinol to prevent attacks.

As has been said, your dose of Atorvastatin is relatively low.  For how long has Colchicine (0.6 mg, twice daily) been prescribed?

Drug interactions - what are your chances?

by Selwyn - 2023-11-24 13:17:17

An individual's experience gives no likelyhood of the CHANCES of having a drug interaction. 

For a review see: Pharmacotherapy
. 2022 Apr;42(4):320-333.  doi: 10.1002/phar.2674.

https://pubmed.ncbi.nlm.nih.gov/35175631/

Your colchicine dose is on the high side. Hopefully your kidney and liver function are normal. Hopefully if is only a short course.. Colchicine is horrible stuff, frequently associated with gastrointestinal side effects.  Needs must? There are alternatives.

 

Drug interactions

by Rch - 2023-11-28 23:56:32

Here is my 2 cents on this!

15 mg Atorvastatin is an odd dose, either it's 10 or 20 mg. In any case you would need to switch to a water soluble Statin, not primarily metabolized via CYP 3A4, such as Pravastatin or Rosuvaststin. Please discuss with your Provider. 

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