ENTRESTO Is it beneficial and what about cost?

I have been prescribed ENTRESTO by my cardiologist. In trying to fill the prescription I find out I have to pay $426 for my first 90 days 2x, this is $300 to meet a brand name deductible, then $126 to fill the script and thereafter. That's a lot for me. My questions- 1. In your experience is it worth it?  2. What are you paying for it? I have Heart Failure With Preserved Ejection Fraction and apparently ENTRESTO is the only approved treatment for it, thanks for any advice.



by Old male - 2021-09-27 19:08:54

$42 for 30 days is what I pay until I reach the coverage gap about the 4th month each year due to combined cost of 2 other Tier 3 meds.  Been taking about 3 or 4 years now and noticed it definitely helped when I first started taking.  Have a friend who was on heart transplant list started taking a year ago and doing much better except he's not following doctors recommendations as to  diet and exercise.  Try it.

drug costs

by Julros - 2021-09-27 20:30:44

You likely have Medicare, so I suggest exploring the different Medicare D plans to see what the best coverage would be for next year. 

Unfortunately, this is the game Americans must play  for effective, affordable medications. 



by simonsimon - 2021-09-27 21:01:21

Thanks, great information 


Drug costs

by AgentX86 - 2021-09-27 22:11:25

Yeah, that's what we get for subsidizing the rest of the world's drug costs.

Drug costs

by IAN MC - 2021-09-28 08:50:49

No that's what you get in the U.S. for  having a healthcare system based on PROFIT !


by Stevi - 2021-09-29 00:21:48

I have been on Entresto for about a year.  We started low and I am now at the top dose.   Since I am in Canada cost isn't as much of an issue for me.  Initially I paid about 20% then the provincial government agreed I needed it so they decided to cover it for me.  Now once I make my provincial deductible (about $1300) they then cover it fully.  It made a significant difference.  I at least didn't tire as much and E/F rate improved.  It might be worth seeing if the manufacturer will cover some of the cost for you.  I forgot the maker but you should be able to find out who they are and their contact information via Google.  My personal experience is that some manufacturers will help you when all other options have been explored.  Just for information purposes if it wasn’t covered for me it would cost me $239.70 for 28 days supply..


by simonsimon - 2021-09-29 02:21:34

Thanks Stevi, today I contacted the manufacturer Novartis and filled out a form for assistance, i'll see what happens. I am going to go for it I think, it seems to have helped a lot of people. 


by Kungpow9960 - 2021-10-16 14:48:21

I've been taking Entresto for about five months now. Started at the lowest dose and my Dr. titrated up over time until now I've been on the max dose for a couple months. I think I have noticed a difference, especially when exercising (running). My endurance is very limited thanks to my low EF, but it does seem like since getting on the full dose, it's improved somewhat. 

We will see later this fall when I have another echo if it's a real effect or just placebo on my part!

In terms of payment, I usually pay $35.00 for a 30 day supply. I may look to switch over to a 90 day supply by mail soon though, which would run me $78.00 through Express Scripts (I'm in the US and on my employer's insurance). 

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